Doctor’s Best Best Vitamin C 500mg, 120 Count

(35 Reviews)
Product Id: 259138
Brand: Doctor's Best

Price: $16.04

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Orders ship within 5 to 10 business days. All products are manufactured in the United States, orders handling time within 24 hours (up to 48 hours).

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5 Great reasons to buy from us:

Features

  • Best Vitamin C featuring Quali -C provides a brand of ascorbic acid manufactured in Scotland prized for its quality and reliability
  • Vitamin C is essential to the biosynthesis of the metabolic facilitator L-carnitine, the neurotransmitter norepinephrine, and the main connective tissue in the body, collagen
  • Ascorbic acid is invaluable to the body for its role as an electron donor, supporting numerous metabolic enzymes in addition to enhancing the body's total antioxidant potential
  • Vegetarian
  • Label images may vary

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Doctor's Best Best Vitamin C 500mg, 120 Count

Doctor's Best Best Vitamin C 500mg, 120 Count

Doctor's Best Best Vitamin C 500mg, 120 Count

Doctor's Best Best Vitamin C 500mg, 120 Count

Doctor's Best Best Vitamin C 500mg, 120 Count

Doctor's Best Best Vitamin C 500mg, 120 Count

Doctor's Best Best Vitamin C 500mg, 120 Count

Doctor's Best Best Vitamin C 500mg, 120 Count

Doctor's Best Best Vitamin C 500mg, 120 Count

Doctor's Best Best Vitamin C 500mg, 120 Count

From the manufacturer

Vitamin C immune response antioxidant joints and tissue enzyme brain eyes heart circulation

Read more

Vitamin C immune response antioxidant joints and tissue enzyme brain eyes heart circulation

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

**Registered Vitamin C contains Qual**C

Doctor’s Best Vitamin Ccontains Q-C, which is manufactured in Scotland and prized for its quality and reliability. Vitamin C is indispensable to the body for its role in the synthesis of collagen, carnitine, and certain brain chemical transmitters.

Abundant clinical research confirms Vitamin C’s fundamental support for the immune system, brain, eyes, heart and circulation, and all organ systems.*

Vitamin C is also an electron donor, supporting numerous enzymes and enhancing the body’s total antioxidant potential.*

Read more

Vitamin C immune response antioxidant joints and tissue enzyme brain eyes heart circulation


Vitamin C immune response antioxidant joints and tissue enzyme brain eyes heart circulation


Vitamin C immune response antioxidant joints and tissue enzyme brain eyes heart circulation


What are the benefits of Vitamin C contains Qual** C?

  • Helps support a healthy immune system*
  • Helps support the body’s antioxidant potential*
  • Essential cofactor for important enzyme systems*
  • Essential for joints*

Why take Vitamin C with Qual** C?

  • Doctor’s Best uses Quali -C, a brand of ascorbic acid manufactured in Scotland that is prized for its quality and reliability. Ascorbic acid is invaluable to the body for its role as an electron donor, supporting numerous metabolic enzymes in addition to enhancing the body’s total antioxidant potential.*
  • Vitamin C is a key compound in the body’s “antioxidant network,” a chain of synergistic, inextricability linked, well-studied antioxidants that includes glutathione (GSH) and vitamin E.*

How does it work?

  • Essential for the synthesis of collagen, carnitine, and certain brain chemical transmitters. Clinical research confirms vitamin C’s fundamental support for the brain, eyes, heart and circulation, immune system, and all the body’s other organ systems.*
  • When vitamin E neutralizes free radicals it needs to be renewed. Vitamin C can renew vitamin E back to its native form, and is thought to “spare” glutathione in the body as well.*

Read more

Enhances the body’s antioxidant network* – Vitamin C is a key compound in the body’s “antioxidant network,” a chain of synergistic, inextricability linked, well-studied antioxidants that includes glutathione (GSH) and vitamin E. When vitamin E uses its antioxidant function in neutralizing free radicals, it also loses this antioxidant function. Vitamin C can change this status; it can regenerate vitamin E back to its native form, and is thought to “spare” glutathione in the body as well. Importantly, when ascorbate donates an electron and becomes itself oxidized, or “consumed,” the ascorbate radical is relatively harmless.3 In a double-blind, placebo-controlled study in which blood GSH was measured in healthy subjects at several stages, 500 mg of vitamin C taken daily for 2 weeks significantly raised erythrocyte (red blood cell) glutathione levels. The researchers concluded that vitamin C supplementation at that level can benefit the overall antioxidant capacity of the blood.4 In another study of similar design, 1000 mg of vitamin C taken daily for 4 weeks bolstered vitamin E and glutathione content in erythrocyte cell membranes, compared with placebo.5

The highest concentrations of vitamin C in the body are found in the central nervous system (in neurons of the brain & spinal cord) and the adrenal glands. Although the presence of ascorbate in neurons is in part explained by its neuromodulatory enzyme activity, its high concentration suggests that vitamin C is so greatly retained by neurons in order to address the higher rates of oxidative metabolism experienced by the brain. This has led to the conclusion that under normal conditions, vitamin C helps safeguard the integrity of neurons (and therefore the brain), largely through neutralization of the free radicals of reactive oxygen species (ROS).6 Low levels of blood vitamin C and the resulting accumulation of ROS are thought to be detrimental—especially to aging populations.

Supports the Cardiovascular and Immune Systems*

Most prospective studies assessing vitamin C intake in large numbers of people who are followed over time indicate that the highest intakes of vitamin C are associated with enhanced cardiovascular benefits. In addition, some large studies of healthy individuals who take vitamin C supplements suggest that supplementation supports healthy heart function. The Nurses’ Health Study of more than 85,000 women followed for over 16 years found vitamin C intakes of more than 359 mg per day from diet plus supplements or from supplements alone were associated with a more favorable cardiovascular health status.7 In a recent review of studies in which more than 290,000 healthy adults were followed for an average of 10 years, those who took more than 700 mg per day of supplemental vitamin C had a substantially better cardiovascular profile than those who did not take vitamin C supplements.8

Oxidative stress is a central component of cardiovascular health, and vitamin C acts vigorously to counteract multiple avenues of oxidation that detract from cardiovascular health.9 Nitric oxide (NO) produced by endothelial cells (lining blood vessel walls) helps to maintain cardiovascular homeostasis and to safeguard blood vessels. Ascorbate helps to protect the normal NO biosynthesis pathway, which is easily disrupted by ROS.

High levels of certain proteins in the blood serve as indicators of disruptions to both cardiovascular and immune system health. In a study of 3,258 healthy men, levels of vitamin C in the blood have been found to be inversely associated with these protein markers of unbalanced immune activation.10

In a study examining the blood of 240 healthy subjects, the concentration of glutathione and ascorbate was measured in lymphocytes.11 Interestingly, the vitamin C levels of the lymphocytes varied significantly depending on the season (ascorbate levels were lower in the winter), confirming earlier research in which investigators had reported fluctuations in blood vitamin C levels with the seasons. The researchers propose that vitamin C supplementation will not only increase levels of ascorbate in lymphocytes, but GSH levels as well. Although not a controlled clinical trial, the results here are one more piece of the immune system puzzle, and they also hint at what time of year vitamin C supplementation may be most beneficial.

AREAS FOR FURTHER RESEARCH

Results from a pilot study in young adults with either marginal or adequate vitamin C status indicate that vitamin C status impacts fat oxidation.12 The investigators conclude that this is one factor to consider in planning effective weight management strategies.

In a subsequent study of 118 generally sedentary (some normal weight, some overweight) adults aged 20–60, the relationship between vitamin C, body mass index (BMI), and other measures of health was assessed. The researchers found that blood plasma vitamin C concentration was inversely correlated with BMI, percentage of body fat (adiposity), and waist circumference in both the men and women.13 This is particularly interesting because approximately one-third of Americans have marginal vitamin C concentrations. Previous studies also found an inverse relationship between plasma ascorbate and adiposity; it remains unknown whether the increased oxidative stress of carrying additional pounds accounts for this—but research will eventually provide us with an answer.

Scientific References go to Doctor’s Best for more information on Vitamin C.

Product description

Vitamin C is a key compound in the body’s “antioxidant network,” a chain of synergistic, inextricability linked, well-studied antioxidants that includes glutathione (GSH) and vitamin E. When vitamin E uses its antioxidant function in neutralizing free radicals, it also loses this antioxidant function. Vitamin C can change this status; it can regenerate vitamin E back to its native form, and is thought to “spare” glutathione in the body as well. Importantly, when ascorbate donates an electron and becomes itself oxidized, or “consumed,” the ascorbate radical is relatively harmless. In a double-blind, placebo-controlled study in which blood GSH was measured in healthy subjects at several stages, 500 mg of vitamin C taken daily for 2 weeks significantly raised erythrocyte (red blood cell) glutathione levels. The researchers concluded that vitamin C supplementation at that level can benefit the overall antioxidant capacity of the blood. In another study of similar design, 1000 mg of vitamin C taken daily for 4 weeks bolstered vitamin E and glutathione content in erythrocyte cell membranes, compared with placebo. The highest concentrations of vitamin C in the body are found in the central nervous system (in neurons of the brain & spinal cord) and the adrenal glands. Although the presence of ascorbate in neurons is in part explained by its neuromodulatory enzyme activity, its high concentration suggests that vitamin C is so greatly retained by neurons in order to address the higher rates of oxidative metabolism experienced by the brain. This has led to the conclusion that under normal conditions, vitamin C helps safeguard the integrity of neurons (and therefore the brain), largely through neutralization of the free radicals of reactive oxygen species (ROS). Low levels of blood vitamin C and the resulting accumulation of ROS are thought to be detrimental—especially to aging populations.


  1. I have a hard time finding Vitamin C that doesn’t give me a weird reaction like lots of Vit C can do, perhaps since most is corn-based. The non-corn ones are usually expensive.This one seems fine to me, maybe because it’s adequately purified.

  2. Non GMO vit c is hard to come by at this price. Even more so in a 500 mg cap form. So glad I found it!

  3. Exactly what I was looking for!

  4. If you are looking for a high quality ascorbic acid vitamin C, this is one of the best available. I’ve done a great deal of research on vitamin C and in capsule form there is nothing better. I’ve used this product for 6 months and am completely satisfied. Highly recommended.

  5. I purchased this product on the advice of my GP. I have been using this product for over a year. I use it on a daily basis, also my parents whom are both in their 80’s also use this product. Very good product for the price. Would recommend giving it a go, not every-one can tolerate the same types of C vitamins, for we went through several brands before finding this one.

  6. These Vit. C capsules seem to work very well. I was worried about stomach issues (some Vit. C capsules/ or tablets, can irritate the stomach. So far I’ve had no side effects or issues with these. I highly recommend these.

  7. Will reorder like it

  8. This is my favorite – the only one I will buy because it has no bad ingredients like magnesium sterate. If you take vitamin c, choose this one.

  9. Good value high quality product. Great way to get vitamin C for immune system and inflamtion reduction

  10. Only Vit C that I feel works, I buy for the whole family

  11. How do you rate vit c? I trust this brand, and that is about the best I can do. It’s a basic vitamin that I take daily, and it seems just fine. There are no weird fillers, and no digestive side effects.

  12. helps so much with my vitamin C deficiency

  13. It’s ok.

  14. Great product from a good company.

  15. Just starting. Wanted to add to the MSM regimen I’m trying. I can say I’ve been using this brand of Magnesium a couple of years. Will update.

  16. For some reason, it’s become difficult to find Vitamin C that:1. Is Vitamin C only, not a combo with other vitamins.2. Is not 1000 mg or 1000 mg extended release.3. Is not a powder, but in a tablet or capsule instead.4. Is not in a gelatin (non-vegetarian) capsule.These have almost all the features I like without the ones I don’t like. The only drawback (for me) is the lack of bioflavinoids (such as rosehips and a few others), which supposedly enhance the effects of Vitamin C. Still, I’m giving it a 5* rating secondarily for the price,but mainly because it’s somewhat difficult to find VItamin C with the four qualities listed above.

  17. After reading up on reviews for the best vitamin C to take, I came across this brand. I can’t tell you for sure if these are really any better for us, but my husband and I both love these capsule vitamin C’s better than the tablets we have always been taking. My husband always had trouble swallowing the vitamin c tablets, saying they would get stuck in his throat. He has no problem with these.

  18. Very happy with Doctor’s Best Vitamin C.

  19. Very good product.

  20. Nice!

  21. excellent product, use daily

  22. So far so good. I feel like I’m absorbing this brand of Vitamin C better than the last one I bought. This is the third variety of Doctors Best supplements I’ve used, I will probably try more as I’m happy with the quality.

  23. Good value

  24. Item was correctly and as promised.

  25. Great quality supplement for a good price. I am a firm believer that Doctor’s Best ARE the best!

  26. very fast shipping! so far this has worked really well for my family

  27. Got these for my wife as she has hard time swallowing a lot of pills that are too big.These are very small compact capsules that she is having no issues with swallowing!

  28. I have taken a Vitamin C supplement for years and these are by far the easiest to take. The Vit C is in the form of a small lightweight capsule and is so easy to swallow. No more massive pills for me! I am sure the delivery of the Vit C is a lot more efficient too.

  29. My go to vitamin C product. Helps me stay well during the times when everyone else is sick. Been taking it for years.

  30. Have been getting this for long time now. I think it absorbs well and works better than other brands I’ve tried.

  31. So far so good. Easy to swallow. I like it when its in a form of a Capsule.

  32. This product works like every other vitamin except it has a boost that is perceivable.

  33. I researched for a long time the best vitamins to take for the target of my goals. These were ranked in the top ten of best vitamins for 2019. I was impressed, too. The potency is exactly as advertised. Easy to swallow, no after taste and a great value for the money!

  34. I love the much smaller size! Obviously less fillers than my other 500mg caps!!!

  35. Since it is now flu season, I like to start boosting my immune system. I use vitamin C daily as one of the boosting regimens. This is a decent Vitamin C.

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